Estrogen Receptor Α Enhances the Rate of Oxidative Dna Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus*
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چکیده
TARGETING AN EQUINE ESTROGEN CATECHOL METABOLITE TO THE NUCLEUS* Zhican Wang, Gihani T. Wijewickrama, Kuan-wei Peng, Birgit M. Dietz, Long Yuan, Richard B. van Breemen, Judy L. Bolton, Gregory R. J. Thatcher Department of Medicinal Chemistry and Pharmacognosy (M/C 781) College of Pharmacy, University of Illinois at Chicago 833 S. Wood Street, Chicago, Illinois 60612-7231 Running title: Estrogen receptor alpha enhances oxidative DNA damage Address editorial correspondence to: Dr. Judy Bolton or Dr. Greg Thatcher, 833 S. Wood Street, Chicago, IL, 60612-7231. Fax: (312) 996-7107; E-mail: [email protected]; [email protected]
منابع مشابه
Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus.
Exposure to estrogens increases the risk of breast and endometrial cancer. It is proposed that the estrogen receptor (ER) may contribute to estrogen carcinogenesis by transduction of the hormonal signal and as a "Trojan horse" concentrating genotoxic estrogen metabolites in the nucleus to complex with DNA, enhancing DNA damage. 4-Hydroxyequilenin (4-OHEN), the major catechol metabolite of equin...
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تاریخ انتشار 2009